This study investigated the application effects of information-based health management combined with the knowledge-attitude-practice (KAP) health education model in hypertensive patients. Two hundred hypertensive patients were randomized into a control group or an intervention group. Patients in the control group received conventional health management and health education, whereas those in the intervention group received information-based health management plus the KAP health education model. The blood pressure control rate, pre- and post-management systolic and diastolic blood pressures, medication adherence, self-management abilities [assessed using the Hypertension Patient Self-Management Behavior Rating Scale (HPSMBRS)], health behaviors [examined using the Health-Promoting Lifestyle Profile II (HPLP-II)], quality of life [estimated using the Generic Quality of Life Inventory-74 (GQOLI-74)], and patient satisfaction with management were compared between the two groups. Following management, the blood pressure control rate in the intervention group was higher relative to the control group (P<0.05). Compared to pre-management levels, both groups showed noticeable reductions in systolic and diastolic blood pressures post-management, with lower values observed in the intervention group (P<0.05). Both groups exhibited increased medication adherence, self-management abilities, health behavior scores, and quality of life, with higher values in the intervention group (P<0.05). Patient satisfaction with management was higher in the intervention group (P<0.05). Information-based health management plus the KAP health education model effectively improved blood pressure control, medication adherence, self-management ability, health behaviors, and quality of life in patients with hypertension, with high patient satisfaction.